In order to experimentally quantify aero-thermo-acoustic performance of work addition processes (such as fans), unique instrumentation is necessary to provide instantaneous velocity, density and temperature fields. Decoupling the effect of flow parameters on the sensor output signal is considered to be one of the historic challenges. In this regard, we are working on advanced 4-wire hot wire anemometry technique that is able to decouple such fluctuations from the mainstream flow processes. Experimentally characterizing the Nusselt-Reynolds relation over each wire in a simple calibration process, and accounting for the compressibility effects by semi-empirical Mach corrections, the heat transfer behavior of each thin heated filament can be accurately described. By deriving the sensitivity of each variable theoretically, we are able to attain a reasonably non-singular sensitivity matrix, formed by optimal selection of wire diameters and temperatures.